The state of one’s digestive system has a significant impact on immunological response, nutrient absorption, and general quality of life. Interest in the effects of particular minerals, like glycinate and citrate, on the digestive system has risen in recent years.

The purpose of this article is to investigate the effects of glycinate plus citrate on the health of the digestive system. Understanding these minerals’ characteristics and mechanisms of action will help us understand how they could improve digestion and support a healthier gastrointestinal tract.

Glycinate VS citrate, both are commonly used forms of mineral supplements with different characteristics. Glycinate is a great option for people with digestive sensitivity because of its high absorption and gentle nature.

On the contrary, citrate is frequently chosen because of its ability to control acidity, making it excellent for people who want to promote urinary health.

What Is The Impact Of Glycinate And Citrate On Digestive Health?


Glycinate refers to a chemical compound that is derived from the amino acid glycine. Glycine itself is the simplest amino acid and is involved in various physiological processes in the human body. When glycine is combined with another molecule or element, such as a metal ion, it forms a compound known as a glycinate.

In this case, glycine is bound to a mineral, typically magnesium. This form of mineral supplementation offers several advantages for digestive health.

a. Enhanced Absorption:

Glycinate chelates are highly bioavailable, meaning they are easily absorbed and utilized by the body. This improved absorption ensures that the mineral reaches the digestive system efficiently, where it can exert its beneficial effects.

b. Alleviating Constipation:

 Magnesium glycinate has been reported to have a gentle laxative effect, making it useful in relieving constipation. By promoting regular bowel movements, glycinate supplements can contribute to maintaining a healthy digestive system.

c. Reduced Digestive Discomfort:

Magnesium glycinate is known to have a calming effect on the muscles of the gastrointestinal tract. This can help alleviate symptoms of digestive discomfort, such as bloating and cramping, making it a suitable choice for individuals with sensitive digestive systems.


Citrate is another name for citric acid, an organic acid with low strength that is found in citrus fruits such as limes, lemons, citrus fruits, and grapefruits. The ionized version of citric acid is called citrate.

The cycle of citric acid, also known as the Krebs cycle or the cycle of TCA, is an essential metabolic process in the majority of living things. A critical component of this cycle is citric acid. Citrate is often used in the form of salt in a range of industries and applications due to its adaptability.

a. Acid Neutralization:

Calcium citrate has an alkalizing effect on stomach acid, helping to neutralize excessive acidity. This property can be particularly beneficial for individuals with conditions like acid reflux or GERD, as it helps reduce discomfort and promote a more balanced pH in the digestive system.

b. Improved Calcium Absorption:

Calcium citrate supplements have a higher bioavailability than other calcium supplements. This enhanced absorption makes sure that enough calcium gets to the intestines so that the body can effectively absorb and use it. Getting enough calcium is essential for keeping your digestive system in good shape.

c. Prevention of Oxalate Formation:

Citrate has been found to inhibit the formation of calcium oxalate crystals in the kidneys. This property is especially relevant to individuals prone to kidney stone formation, as it can help prevent the accumulation of these crystals, reducing the risk of kidney stone-related digestive issues.

Synergistic Effects:

When glycinate and citrate are combined, they can have synergistic effects on digestive health. The alkalizing properties of citrate can help counteract the potential negative effects of excess stomach acid, while glycinate aids in the breakdown and absorption of nutrients.

This combination may be particularly beneficial for individuals with conditions such as indigestion or acid reflux.

Side Effects and Precautions:

Although glycinate and citrate are usually thought of as safe for the majority of people, it’s vital to remember that everyone reacts differently.

Some people might develop negative side effects including gastrointestinal discomfort, such as bloating, gas, or diarrhea. Starting with smaller doses and gradually increasing them as tolerated is advised.

Additionally, before adding glycinate or citrate vitamins to their regimen, anyone with particular medical issues or those who are taking drugs should speak with a healthcare provider.

These supplements may interfere with some drugs, such as Antacids or diuretics, necessitating changes to dosage or timing.


Finally, selecting the best vitamins can have a big impact on digestive health. In this respect, glycinate and citrate each have particular advantages. Glycinate, particularly magnesium glycinate, can ease stomach discomfort, ease constipation, and encourage regular bowel movements.

On the contrary hand, citrates, like calcium citrate, can help neutralize acids, improve calcium absorption, and stop kidney stones from forming.

To choose the best supplement form for a person’s needs and gastrointestinal health issues, they must speak with a medical practitioner or a qualified dietitian. Keep in mind that maintaining maximum well-being requires an integrated approach to digestive wellness, including a nutritious diet and a healthy lifestyle.

Also, read this: The top 5 health benefits of nutmeg are numerous